Combination gefitinib and methotrexate compared with methotrexate alone to treat ectopic pregnancy

MM Skubisz; AW Horne; TG Johns; UW Nilsson; WC Duncan; EM Wallace; HOD Critchley; S Tong

Journal article

Combination gefitinib and methotrexate compared with methotrexate alone to treat ectopic pregnancy

MM Skubisz, AW Horne, TG Johns, UW Nilsson, WC Duncan, EM Wallace, HOD Critchley, S Tong

Obstetrics and Gynecology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2013

DOI: 10.1097/AOG.0b013e3182a14cfb

Abstract

OBJECTIVE: To determine the safety, tolerability, and efficacy of combination gefitinib and methotrexate to treat ectopic pregnancy. METHODS: We performed a phase I, single-arm (nonrandomized), open-label study. Twelve women with ectopic pregnancies were administered methotrexate (50 mg/m2, intramuscular) and 250 mg oral gefitinib in a dose-escalation protocol: one dose (day 1) n53; three doses (days 1-3) n53; seven doses (days 1-7) n56. Efficacy was examined by comparing human chorionic gonadotrophin (hCG) decline and time to resolution with historic controls administered methotrexate only. RESULTS: Common side effects were transient acneiform rash in 67% (8/12) and diarrhea in 42% (5/12) o..

View full abstract

University of Melbourne Researchers

Stephen Tong Author

Related Projects (2)

DEVELOPMENT OF NOVEL MEDICAL THERAPIES TO CURE ECTOPIC PREGNANCIES

Ectopic pregnancies are conceptions implanting outside the womb, mainly the fallopian tube. They are pathological, and can erode straight th..

DEVELOPING MOLECULAR THERAPEUTICS AND DIAGNOSTICS FOR PREGNANCY COMPLICATIONS

Pregnancy complications still causes the death of mothers, and their babies. During this fellowship, we will be developing new treatments an..

Grants

Awarded by Medical Research Council

Funding Acknowledgements

Supported by National Health and Medical Research Council of Australia (NHMRC) Project Grants #606611 (S. T. and T.G.J.) and #1008276 (S. T., E. M. W., and T.G.J.); NHMRC Career Development Fellowship #1050765 (S. T.); The Monash Institute of Medical Research Flagship Grant (S. T., T.G.J., E. M. W.); Medical Research Council Clinician Science Fellowship (A. W. H.); Medical Research Council Centenary Award #G0802808 (A. W. H.); The Helen MacPherson Trust (S. T.); and The Victorian Government's Operational Infrastructure Support Program (M. S., T.G.J., and E.M.W.).